This presentation, delivered by Thomas Lweya, EPI Coordinator for Ntchisi District in Malawi, highlights the training of healthcare professionals at the district level during HPV vaccine introduction. It outlines the district’s context, the vaccination rollout strategy, and challenges such as staff turnover, incomplete training of nurses and clinicians, and lack of reliable eligibility data. The lessons learned emphasize the need for timely and comprehensive training, refresher sessions, and close collaboration with education and community stakeholders. Future efforts will focus on integrating HPV vaccine content into training curricula and improving planning and mentorship to strengthen routine vaccination delivery.