The presentation from Pakistan outlines the preparatory work for introducing HPV vaccination into the national immunization program, which is not yet implemented despite significant disease burden. Cervical cancer ranks as one of the top causes of female mortality, with 5,000–7,000 new cases annually. A national roadmap was mandated by the Ministry of Health and EPI, focusing on landscape analysis, cost-effectiveness, and advocacy with federal and provincial stakeholders. Recommendations include developing a comprehensive policy, integrating HPV vaccination into routine and campaign strategies, and addressing stigma through culturally sensitive communication. Pakistan’s strong track record in introducing new vaccines (e.g., pentavalent, pneumococcal, rotavirus, typhoid) and its established cold-chain capacity provide a solid foundation. Economic analysis by Johns Hopkins’ International Vaccine Access Center shows HPV vaccination to be cost-effective, with school-based strategies expected to reach about two-thirds of target girls. However, challenges remain, such as polio eradication demands, decentralization, and mobilization for out-of-school adolescents