Nepal’s HPV vaccination campaign, launched on 4 February 2025, targeted 1.6 million girls (grades 6–10 and out‑of‑school girls aged 10–14), achieving 94% coverage with single‑dose Cecolin. The program utilized 18,900 schools and 8,200 health facilities, with 51,483 female community health volunteers and 27,000 health workers mobilized. Youth‑led advocacy, child clubs, and digital social listening strategies were leveraged to combat misinformation and engage communities. High‑level political support included involvement of the Prime Minister, Ministers of Health and Education, and goodwill ambassador Manisha Koirala. The campaign showcased strong multisectoral collaboration between health, education, and local governments.