In Kenya, a dual-strategy implementation study addressed two persistent barriers to HPV vaccination coverage — vaccine hesitancy and dependence on inconsistent school-based outreach — through complementary school engagement and facility-based OPD screening models. The Ministry of Education–led school engagement component deployed school health committees, teacher training, health club reactivation, and peer-led forums nationwide, generating qualitative improvements in caregiver trust and normalisation of HPV conversations, without reporting numeric vaccination counts. The facility-based OPD screening model, implemented across 85 facilities in 11 counties, found that 68% of girls aged 10–14 attending outpatient services were unvaccinated but eligible (9,521 of 13,901 visits over four months), with a Kisii pilot achieving 95% same-day vaccination among eligible girls; facilities with OPD screening recorded 1.8× higher HPV-1 and 2× higher HPV-2 coverage than non-screening sites, with national scale-up projected to reach an additional 196,020 girls per month.