This poster details Abia State’s experience during Nigeria’s first HPV vaccine rollout in 2023, targeting girls aged 9–14 through school and community outreach. It highlights social mobilization efforts, including engagement with over 3,500 schools and the Ministry of Education’s role in coordination. Key challenges included funding gaps, overlapping health programs, and school participation barriers. Lessons emphasize integrating education stakeholders early and adapting strategies for subsequent rollout phases.