This presentation from Zambia reflects on the country’s experience with HPV vaccination, particularly focusing on coverage trends, delivery strategies, and the unique challenges of vaccinating adolescent girls. The national HPV vaccination program was launched in 2019 using a school-based campaign strategy, targeting girls aged 9–14. While initial uptake was strong, the COVID-19 pandemic caused major disruptions, leading to a drop in coverage and logistical delays in implementing the planned multi-age cohort catch-up campaign. To reach out-of-school girls, Zambia relied on community outreach and fixed-post strategies, including continued vaccination during Child Health Weeks. One major lesson learned was the difficulty of reaching girls aged 13–14, who often change schools or life status (e.g. early marriage, motherhood), making follow-up for the second dose nearly impossible. As a result, Zambia plans to shift its target group to 9-year-olds going forward, as they are more likely to be consistently enrolled in school. The program also highlighted the need to adapt communication approaches—not only targeting mothers, as with infant vaccines, but also directly engaging girls, teachers, and even health workers. Vaccine hesitancy, misinformation about infertility, and poor collaboration between volunteers and health facilities were noted as persistent barriers. Additionally, Zambia acknowledged gaps in standardized data collection tools and the challenge of promoting a vaccine whose benefits are not immediately visible. Looking ahead, the country aims to improve stakeholder alignment and strengthen outreach to better address the unique challenges of adolescent immunization.