In Cameroon, DHIS2 centralizes health data from approximately 6,000 health facilities, with monthly reporting cascading from facility to district, regional, and national levels. The presentation identifies five key gaps in the HPV health information system: limited integration of school registers into microplanning, absence of age-cohort disaggregation for catch-up targets, delayed and incomplete facility reporting, lack of individual vaccination tracking, and limited data use capacity at district level. Sub-national challenges include geographical disparities, population mobility (IDPs, refugees, nomadic groups), variable school attendance, and sociocultural barriers including vaccine hesitancy linked to early Catholic Church opposition. Key interventions include digital microplanning integrating school and geospatial data, integrated real-time dashboards, institutionalized quarterly data reviews across all 206 health districts, and data-driven PIRI targeting. Lessons highlight that digital tools must be paired with capacity building, and that a data use culture at operational level is essential for sustained programmatic impact.