In Uganda, HPV vaccination began with a 2007 pilot project, expanded to a national rollout in 2015 targeting 10-year-old girls through a hybrid school- and age-based model. The presentation traces the programme’s milestones including post-introduction evaluations, COVID-19 disruptions, and post-pandemic recovery. Delivery relies on routine immunization infrastructure, with most vaccinations occurring biannually during Integrated Child Health Days. Uganda switched to a single-dose schedule in January 2025 following NITAG recommendation. Key enablers include strong political commitment, established cold chain and HR infrastructure, school mapping linked to health facilities, and multi-partner coordination (World Bank, GFF, Gavi, UNICEF). Persistent challenges include demand generation, reaching out-of-school and hard-to-reach girls, data quality, weak multisectoral collaboration with private schools, and emerging vaccine shortages post-switch. Future priorities focus on microplanning, institutionalising ICHDs, systematic school registration, intersectoral supervision, and ensuring two-dose protection for immunocompromised girls.