The presentation outlines Myanmar’s policy shift from a two-dose to a single-dose HPV vaccination schedule, driven by operational challenges during COVID-19, missed cohorts, and WHO’s updated recommendations. NITAG adopted a systematic, evidence-based approach using PICO criteria to guide decision-making, ensuring transparency and technical rigor. The revised strategy targets 9–11-year-old girls through school and community campaigns, prioritizing catch-up for missed doses. This policy aims to optimize coverage, resource utilization, and alignment with global cervical cancer elimination goals.