Dr. Safdar Nosheen (WHO AFRO) presented critical epidemiological data at the 2025 CHIC Symposium, emphasizing that Africa bears a disproportionate burden of HPV-related diseases, with 18 of the 20 highest-burden countries globally located in the region. In sub-Saharan Africa, cervical cancer accounts for approximately 30% of female cancer diagnoses, with mortality rates reaching 23 per 100,000 women annually. The intervention highlighted a significant implementation gap where high-incidence countries often have the lowest vaccine coverage. Priorities include narrowing this equity gap through sustained, high-quality vaccination programs and integrated planning to address both cervical and non-cervical HPV-related cancers.