In Zambia, the HPV vaccine was introduced nationwide in 2019, targeting 9-year-old girls in routine vaccination with catch-up for ages 10–14. The country has since adopted a single-dose schedule for non-immunocompromised girls and transitioned to a routine service delivery model, both informed by the Zambia Immunisation Technical Advisory Group based on evidence of comparable efficacy, programmatic efficiency, and anticipated cost-effectiveness. Service delivery combines school-based outreach (primary platform), health facility, and community outreach, with Child Health Weeks and Africa Vaccination Weeks used for additional catch-up. Coverage is tracked through an HPV Tracker system, with consistently higher rates in the north and persistent gaps in Central, Western, and Lusaka provinces. The long-term coverage target is 90% of girls fully vaccinated by age 15, supported by government and Gavi co-financing and strengthened MOH–MOE collaboration at all levels.