This CHIC briefing document provides a concise overview of HPV disease burden, vaccination programmes, and key challenges facing low- and middle-income countries. It describes HPV as the most common sexually transmitted infection globally, responsible for over 630,000 new cancer cases and 311,000 deaths annually, with 530,000 being cervical cancers. The brief highlights that over 85% of the global burden falls on LMICs, yet fewer than 30% of LMICs had introduced HPV vaccination at the time of writing, compared to over 85% of high-income countries. Key barriers cited include limited financial resources, insufficient vaccine supply (only three WHO-prequalified manufacturers as of early 2021), and COVID-19-related disruptions to supply chains and programme delivery. The document frames the CHIC initiative as a multi-partner effort by IVAC at Johns Hopkins, Jhpiego, University of Antwerp, and LSHTM, aiming to accelerate HPV vaccine introduction and scale-up in LMICs toward the WHO target of 90% coverage among girls under 15.