Lao PDR is undergoing a phased transition from Gavi-supported vaccine financing toward full self-financing by 2025, with projected co-financing obligations steadily increasing. HPV vaccination, introduced in 2020 and procured through UNICEF, targets 10-year-old girls with a single-dose schedule, requiring fewer than 100,000 doses annually at an estimated cost of USD 500,000. The country has consistently met co-financing obligations and engages in consultative forecasting through technical working group meetings. Strategic priorities include strengthening financial management, aligning district-level planning with realistic budgets, and ensuring sustainable funding mechanisms post-Gavi. Future challenges will focus on maintaining high coverage amid funding shifts, expanding community outreach, and integrating HPV within broader immunization strategies.