Dr. Ibrahima Diarra from Mali’s Expanded Program on Immunization detailed the country’s HPV vaccination journey, starting with a Gavi-funded pilot (2015–2018) in Bamako Commune V and Fana district. The program demonstrated feasibility and generated strong public demand, supported by national leadership and October’s “Pink October” campaigns. Mali will introduce a single-dose Gardasil vaccine targeting 10-year-old girls in November 2024, focusing on routine services rather than mass campaigns due to resource and security constraints. Strategies combine school-based delivery (covering public, private, and Koranic schools) and outreach to reach non-schooled girls for equity. Population estimates leverage the 2023 census, projecting 267,942 girls for vaccination with a 90% coverage goal. Budget priorities include training (41%), social mobilization (28%), and logistical support, emphasizing microplanning and multi-sectoral coordination.