HPV vaccine delivery in Gavi-supported countries relies mainly on school-based platforms, complemented by outreach to reach out-of-school adolescents. Microplanning and joint coordination between health and education sectors ensure accurate cohort targeting and smooth logistics. Community engagement—through parent meetings, religious leaders, and media—helps address stigma and hesitancy. Trained vaccinators and health workers manage administration and adverse events, supported by clear consent and communication strategies. Integration with adolescent health services and the shift to single-dose schedules simplify delivery and reduce dropouts. Key enablers include political commitment, tailored messaging, and robust data systems to track and sustain high coverage.