This presentation outlines Kenya’s experience with HPV vaccine delivery, from demonstration to national rollout. A demonstration project conducted in Kitui County between 2013 and 2015 through a school-based program achieved high acceptability and over 85% coverage, but the delivery cost was high. These findings informed Kenya’s decision to introduce HPV vaccination into its routine immunization schedule in 2019, targeting 10-year-old girls in school and in the community using a two-dose schedule administered six months apart. The initial rollout was challenged by the timing of school closures and the COVID-19 pandemic, resulting in low coverage (5.8% in 2019). In response, the country adopted multi-age cohort strategies and periodic intensification of routine immunization, increasing dose-one coverage to 41% by 2022. Post-pandemic, Kenya leveraged school-based outreach, community health volunteers, and integration with other services to reach girls more effectively. Specific efforts included linking health facilities with school leadership, conducting training for both immunizing and non-immunizing health workers, and developing simplified communication tools. The Ministry of Health also conducted performance reviews and surveys in low-performing counties to inform strategic planning. Key challenges included low demand, school calendar disruptions, fragmented partner coordination, and limited funding. Kenya’s key lessons emphasize the value of integrating HPV vaccination with broader health services, maintaining strong school–health facility linkages, and tailoring strategies to local contexts through community-level engagement and ongoing supervision.