In Nigeria, HPV vaccination was introduced in two phases — Phase 1 targeting 16 states (2023) and Phase 2 covering 21 additional states (October 2024) — with immediate routinization following each mass multi-age cohort (MAC) campaign. Combined MAC and routine delivery reached approximately 15.3 million girls aged 9–14 since introduction, with over 12.3 million vaccinated through campaigns alone. From 2025, national policy shifted to focus routine delivery on 9-year-old girls, though some states continue vaccinating broader age cohorts. Key enablers include Nigeria’s established EPI infrastructure, strong multisectoral collaboration involving religious and traditional leaders — critical in overcoming hesitancy framing HPV vaccination as permissive of sexual activity — and a phased rollout strategy that allowed lessons from Phase 1 to meaningfully improve Phase 2 performance. Persistent challenges include suboptimal facility-level uptake post-campaign, inconsistent DHIS2 reporting, cold chain and last-mile delivery gaps particularly in northern and conflict-affected states, and significant equity gaps in reaching out-of-school girls. Sustainability plans emphasize progressive domestic financing, institutionalized training, digital supply chain tracking, and community-embedded demand generation to reduce reliance on partner-driven campaigns.